Description

(R)-4-Aminopyrrolidin-2-One Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. This compound is valued for its role as a key synthon in the synthesis of complex, biologically active molecules, particularly those targeting the central nervous system. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in neuroscience and psychiatric disorder research.
• API Synthesis: Used in the development and scale-up production of Active Pharmaceutical Ingredients (APIs) that incorporate the 2-pyrrolidinone pharmacophore.
• Asymmetric Synthesis: Serves as a precursor for chiral catalysts or ligands used in stereoselective chemical transformations.
• Biochemical Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetics: Acts as a constrained scaffold or surrogate in the design of peptide-like molecules with enhanced metabolic stability.
• Reference Standard: Supplied as a high-purity compound for use as an analytical standard in quality control and regulatory submissions.

Basic Information

Product Name	(R)-4-Aminopyrrolidin-2-One Hydrochloride
CAS No.	1292324-66-3
Molecular Formula	C₄H₉N₂O•HCl
Molecular Weight	152.59 g/mol
Synonyms	(R)-4-Amino-2-pyrrolidinone hydrochloride; (R)-4-Aminodihydro-2(3H)-furanone hydrochloride; (R)-4-Aminopyrrolidin-2-one HCl; (R)-4-Amino-γ-butyrolactam hydrochloride; (R)-4-Aminobutyrolactam hydrochloride; (R)-4-Aminopyrrolidinone hydrochloride; (R)-4-APO HCl; (R)-4-Amino-2-oxopyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-4-Aminopyrrolidin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity (typically ≥98% by HPLC), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.