Description

Bis(3-Sulfonatophenyl)(2-Trifluoromethylphenyl)Phosphine, Disodium Dihydrate, Min. 97% (o-Danphos) is a high-purity, water-soluble phosphine ligand designed for advanced catalytic applications. Its value lies in its unique combination of a sulfonated hydrophilic group and a trifluoromethyl-substituted hydrophobic aryl group, which facilitates reactions in aqueous or biphasic systems. This ligand is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing and scaling up palladium-catalyzed cross-coupling reactions like Suzuki-Miyaura and Heck reactions.

Application

• Aqueous-Phase Cross-Coupling Catalysis: As a key ligand for palladium catalysts in Suzuki, Heck, and Sonogashira reactions performed in water or water/organic solvent mixtures.
• Pharmaceutical Intermediate Synthesis: Enabling the efficient and scalable production of complex drug molecules and advanced intermediates under greener conditions.
• Fine Chemical Manufacturing: Used in the synthesis of specialty chemicals, agrochemicals, and performance materials where catalyst recovery and recyclability are important.
• Homogeneous Catalysis Research: A valuable tool for academic and industrial R&D in developing new catalytic methodologies for C-C and C-X bond formation.
• Ligand for Biphasic Systems: Facilitates catalyst separation and recycling in fluorous biphasic catalysis due to the presence of the trifluoromethyl group.

Basic Information

Product Name	Bis(3-Sulfonatophenyl)(2-Trifluoromethylphenyl)Phosphine, Disodium Dihydrate
CAS No.	1289463-84-8
Molecular Formula	C19H12F3Na2O8PS2 • 2H2O
Molecular Weight	606.37 g/mol (Anhydrous basis: 570.36 g/mol)
Synonyms	o-Danphos; 2-Di(3-sulfonatophenyl)phosphino-α,α,α-trifluorotoluene Disodium Salt Dihydrate; Disodium 2-[bis(3-sulfonatophenyl)phosphino]-α,α,α-trifluorotoluene Dihydrate; 2-(Bis(3-sulfonatophenyl)phosphino)-α,α,α-trifluorotoluene Disodium Salt; Water-Soluble Trifluoromethylated Phosphine Ligand; Sulfonated Phosphine Ligand; BTPPTS (Bis(3-sulfonatophenyl)(2-trifluoromethylphenyl)phosphine trisodium salt is a related compound).
EINECS	Contact for details

Quality Control

Our o-Danphos is produced under strict quality management protocols to ensure batch-to-batch consistency and high performance. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and residual solvent content is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent oxidation and moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Water Content (KF)	5.0 - 7.0% (Theoretical for dihydrate: ~5.9%)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.