Description

Bis(3-Sulfonatophenyl)(4-Trifluoromethylphenyl)Phosphine Disodium Dihydrate, Min. 97% p-Danphos is a high-purity, water-soluble phosphine ligand, a critical component in advanced catalytic systems. Its value lies in its unique combination of a sulfonated hydrophilic group for aqueous-phase compatibility and a trifluoromethylphenyl moiety for enhanced electron-withdrawing and stability properties. This compound is essential for researchers and manufacturers in pharmaceutical intermediates, fine chemical synthesis, and homogeneous catalysis, where precise ligand control is paramount for reaction efficiency and selectivity.

Application

• Homogeneous Catalysis: As a key ligand in transition metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) performed in aqueous or biphasic systems.
• Pharmaceutical Synthesis: For the production of complex drug intermediates and active pharmaceutical ingredients (APIs) requiring high-purity, water-soluble catalysts.
• Fine Chemical Manufacturing: Enabling selective hydrogenation, hydroformylation, and other specialty chemical transformations under mild conditions.
• Asymmetric Synthesis: Potential use in developing chiral catalysts for enantioselective synthesis, crucial for agrochemicals and fragrances.
• Material Science Research: In the synthesis of functionalized polymers or metal-organic frameworks (MOFs) where water-soluble phosphine ligands are advantageous.
• Green Chemistry Initiatives: Facilitating catalytic processes in water, reducing the need for volatile organic solvents and improving process sustainability.

Basic Information

Product Name	Bis(3-Sulfonatophenyl)(4-Trifluoromethylphenyl)Phosphine Disodium Dihydrate, Min. 97% p-Danphos
CAS No.	1289463-79-1
Molecular Formula	C19H13F3Na2O8PS2 • 2H2O
Molecular Weight	~ 610.38 g/mol (anhydrous basis)
Synonyms	p-Danphos; 3,3'-Disulfonato-4'-(trifluoromethyl)triphenylphosphine Disodium Salt Dihydrate; Tris(3-sulfonatophenyl)phosphine derivative; Water-soluble TPPTS analog; Sulfonated phosphine ligand; BTPP; BTPPS; Sodium 3,3'-(phosphinidynedi-4,1-phenylene)bis(benzenesulfonate) derivative
EINECS	Contact for details

Quality Control

Our Bis(3-Sulfonatophenyl)(4-Trifluoromethylphenyl)Phosphine Disodium Dihydrate is manufactured under strict quality management protocols to ensure batch-to-batch consistency and a minimum purity of 97%. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, utilizing analytical techniques such as HPLC, NMR, and ICP-MS. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis customers globally.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Water Content (KF)	5.0 - 8.0% (corresponding to dihydrate)
Heavy Metals (ICP-MS)	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
pH (5% solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.