Description

Prasugrel Metabolite M3 CAS NO 1287383-06-5 is a key active metabolite of the antiplatelet drug Prasugrel. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug development and analytical chemistry.

Application

• Reference Standard for Bioanalytical Assays: Used as a certified standard for the quantification of Prasugrel's active metabolite in biological matrices (plasma, serum) during clinical and preclinical studies.
• Pharmacokinetic and Metabolism Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of Prasugrel.
• Impurity Profiling and Method Development: Serves as a critical impurity marker and system suitability standard in HPLC and LC-MS/MS method development for drug substance and product testing.
• Drug Discovery and Development: Employed in research to understand structure-activity relationships (SAR) and to develop next-generation P2Y12 receptor antagonists.
• Quality Control in Manufacturing: Used as an analytical reference to ensure the consistency and purity of Prasugrel active pharmaceutical ingredient (API) and finished dosage forms.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with FDA, EMA) to demonstrate understanding of the drug's metabolic pathway.

Basic Information

Product Name	Prasugrel Metabolite M3
CAS No.	1287383-06-5
Molecular Formula	C16H17FO3S
Molecular Weight	308.37 g/mol
Synonyms	Prasugrel Active Metabolite; R-138727; (5)-2-[2-(Acetylsulfanyl)-1-cyclopropyl-2-oxoethyl]-5-(2-fluorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one; 2-[1-Cyclopropyl-2-(2-fluorophenyl)-2-oxoethyl]thio-1-cyclopropyl-2-(2-fluorophenyl)ethanone derivative; Prasugrel Metabolite R-138727; Prasugrel Hydrolysis Metabolite; Prasugrel Thiolactone Metabolite
EINECS	Contact for details

Quality Control

Our Prasugrel Metabolite M3 is manufactured under strict quality systems suitable for pharmaceutical research. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of specific impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). For long-term storage, consider storing desiccated at -20°C. The container should be kept in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.