Description

Pac-1-D8 is a deuterated analog of the bioactive compound Pac-1, specifically designed for advanced research and analytical applications. This high-purity labeled standard is critical for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies. It is an essential tool for pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug discovery, development, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical assays for accurate pharmacokinetic and pharmacodynamic studies.
• Metabolite Identification & Profiling: Aids in the detection and structural elucidation of metabolites in complex biological matrices.
• Drug Discovery & Development: Supports research into the mechanism of action, stability, and degradation pathways of the parent compound Pac-1.
• Stable Isotope Labeling Studies: Enables precise tracking and quantification in absorption, distribution, metabolism, and excretion (ADME) research.
• Quality Control & Method Validation: Serves as a critical component in validating analytical methods for regulatory compliance (e.g., FDA, EMA).
• Biomedical Research: Facilitates investigations into apoptosis and related cellular pathways where Pac-1 is utilized as a research probe.

Basic Information

Product Name	Pac-1-D8
CAS No.	1287241-26-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Deuterated Pac-1; Pac-1 (deuterated); [D8]-Pac-1; Procaspase-3 activator-1-D8; NSC 121413-D8; 4,5,6,7-Tetrachloro-2H-isoindole-1,3-dione derivative-D8; WF-210-D8
EINECS	Contact for details

Quality Control

Our Pac-1-D8 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic purity are provided. We support research requiring compliance with cGMP and GLP principles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be allowed to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.