Description

(R)-Carisbamate-D4 is a deuterated isotopologue of the investigational neuroprotective agent Carisbamate, specifically labeled on four hydrogen atoms. This stable isotope-labeled compound is a critical reference standard and intermediate for advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of Carisbamate in biological matrices (plasma, serum, urine).
• Drug Metabolism Studies (DMPK): Used as a tracer in mass spectrometry to elucidate metabolic pathways, identify metabolites, and study the pharmacokinetic profile of Carisbamate.
• Clinical Research & Development: Essential for ensuring data integrity and regulatory compliance in bioanalytical assays during preclinical and clinical trial phases.
• Pharmaceutical Impurity Profiling: Acts as a reference material for identifying and quantifying process-related impurities or degradation products in active pharmaceutical ingredient (API) batches.
• Stable Isotope Labeling Research: Used in mechanistic studies to track the fate of specific molecular fragments within biological systems.

Basic Information

Product Name	(R)-Carisbamate-D4
CAS No.	1287128-99-7
Molecular Formula	C12H11D4NO4
Molecular Weight	237.28 g/mol (for D4 isotopologue)
Synonyms	(R)-2-Hydroxy-2-(4-methoxyphenyl)ethyl carbamate-D4; (R)-RWJ-333369-D4; (R)-1,2-Ethanediol, 1-(4-methoxyphenyl)-, 2-carbamate (D4); SPM 927-d4 (Isotopically Labeled); Carisbamate (D4, (R)-form); UNII-8K713B34YF (related base compound)
EINECS	Contact for details

Quality Control

Every batch of (R)-Carisbamate-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for regulatory bioanalysis and research. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including assay by HPLC, isotopic purity by MS, and chemical purity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, keep the container sealed under an inert atmosphere in a cool, dry place. This material is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (HPLC)	≥95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.