Description

2-[2,2,3,3,5,5,6,6-Octadeuterio-4-[3-[5-Oxo-2-(Trifluoromethyl)Phenothiazin-10-Yl]Propyl]Piperazin-1-Yl]Ethanol is a deuterated derivative of a trifluoromethyl-substituted phenothiazine ethanol compound. This product is a high-value stable isotope-labeled intermediate critical for advancing research in pharmacokinetics and metabolic studies. It is primarily utilized by pharmaceutical R&D organizations and contract research organizations (CROs) engaged in the development of novel therapeutics, particularly within the central nervous system (CNS) domain.

Application

• Internal Standard for Bioanalytical Assays: Serves as a critical reference compound in Liquid Chromatography-Mass Spectrometry (LC-MS) for the quantitative analysis of drug candidates and their metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracer studies to elucidate metabolic pathways, absorption, distribution, and excretion profiles of parent pharmaceutical compounds.
• Pharmaceutical Impurity Profiling: Acts as a labeled standard to identify and quantify process-related impurities or degradation products during drug substance development.
• Preclinical and Clinical Research: Supports non-clinical and clinical trial studies requiring highly specific and sensitive detection methods for accurate pharmacokinetic modeling.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision quantitative methods to ensure accuracy and compensate for analyte loss during sample preparation.
• Reference Material for Method Development: Essential for developing and validating robust analytical methods in compliance with GLP and ICH guidelines.

Basic Information

Product Name	2-[2,2,3,3,5,5,6,6-Octadeuterio-4-[3-[5-Oxo-2-(Trifluoromethyl)Phenothiazin-10-Yl]Propyl]Piperazin-1-Yl]Ethanol
CAS No.	1287047-37-3
Molecular Formula	C22H17D8F3N3O2S
Molecular Weight	Contact for details
Synonyms	10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-2-(trifluoromethyl)phenothiazin-5-one-d8; Deuterated Trifluoperazine Metabolite Intermediate; d8-Labeled Phenothiazine Ethanol Derivative; 2-(Trifluoromethyl)-10H-phenothiazin-5-one-d8 Piperazine Ethanol Derivative; 1-[2-Hydroxyethyl]-4-[3-(5-oxo-2-trifluoromethyl-10H-phenothiazin-10-yl)propyl]piperazine-d8; Stable Isotope-Labeled Trifluoromethylphenothiazine
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing chemical purity, isotopic enrichment (D-content), and confirming identity and structure. Our quality commitment aligns with the standards expected for research-grade reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.