Description

(S)-n-Boc-2-(4-Bromobenzyl)Alanine is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a 4-bromobenzyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and production of peptide-based therapeutics and other advanced drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in peptide and peptidomimetic drug discovery.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a hydrophobic, bromine-functionalized aromatic side chain, enabling structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Serves as a core component in the design and construction of inhibitors targeting specific proteolytic enzymes.
• Chemical Biology & Bioconjugation: The bromobenzyl group provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) for labeling or linker attachment.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in the stereoselective synthesis of more complex organic molecules.
• Academic & Industrial R&D: Essential for medicinal chemistry programs in academic laboratories and contract research organizations (CROs) focused on oncology, neurology, and metabolic diseases.

Basic Information

Product Name	(S)-n-Boc-2-(4-Bromobenzyl)Alanine
CAS No.	1286768-44-2
Molecular Formula	C15H20BrNO4
Molecular Weight	358.23 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-bromophenyl)propanoic acid; (S)-3-(4-Bromophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid; Boc-(S)-4-Bromo-Phe-OH; N-Boc-4-bromo-L-phenylalanine; N-(tert-Butoxycarbonyl)-4-bromo-L-phenylalanine; (S)-N-Boc-4-bromophenylalanine; tert-Butyl (S)-(1-(4-bromophenyl)-3-carboxypropyl)carbamate
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-2-(4-Bromobenzyl)Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.