Description

(R)-Aminofol-D3 CAS NO 1286597-21-4 is a high-purity, deuterated stereoisomer of a key pharmaceutical intermediate, offering enhanced metabolic stability for advanced research and development. This compound is critical for creating more effective and stable drug candidates, particularly in the fields of oncology and metabolic disease research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced chemical synthesis facilities requiring isotopically labeled building blocks with defined chirality.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel deuterated drug candidates, leveraging the kinetic isotope effect for improved metabolic profiles.
• Metabolic Pathway Tracer: Used in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify drug metabolites using mass spectrometry.
• Reference Standard: Serves as an analytical standard for method development and validation in quality control laboratories to ensure the purity and enantiomeric excess of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a metabolically stable analog to probe biological activity and mechanism of action.
• Isotope Labeling: Essential for the preparation of internal standards used in quantitative bioanalytical assays, ensuring high accuracy and reproducibility in clinical trials.

Basic Information

Product Name	(R)-Aminofol-D3
CAS No.	1286597-21-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-Deutero-aminofol; (R)-Aminofol-d3; Deuterated (R)-Aminofol; (R)-2-Amino-1,1,1-trideuterio-folate derivative; (R)-Aminopterin-D3 analog; (R)-4-Aminofolic acid-D3; (R)-D3-Aminofol; Aminofol-(R)-d3
EINECS	Contact for details

Quality Control

Our (R)-Aminofol-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical purity and enantiomeric excess. Certificates of Analysis (COA) detailing identity, purity, and isotopic enrichment are provided with every shipment. We adhere to cGMP guidelines for advanced pharmaceutical intermediates to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.