Description

4-Amino-2,3,5,6-Tetradeuterio-n-(6-Methoxypyrimidin-4-Yl)Benzenesulfonamide is a deuterated derivative of a key sulfonamide-based pharmaceutical intermediate. This compound is specifically designed for use in advanced research and development, offering significant value in metabolic and pharmacokinetic studies due to its isotopic labeling. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly in the areas of enzyme inhibition and drug discovery.

Application

• Pharmaceutical Reference Standard: Serves as a critical internal standard in quantitative LC-MS/MS analysis for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: The deuterium labeling enables precise tracking of the parent compound and its metabolites in biological systems.
• Drug Discovery Intermediate: Used in the synthesis and optimization of new chemical entities targeting specific biological pathways, often related to its sulfonamide pharmacophore.
• Proteomics & Biochemical Research: Employed as a tool compound in enzyme inhibition assays and mechanistic studies.
• Stable Isotope Labeling: Provides a non-radioactive means of labeling for use in mass spectrometry-based assays, enhancing detection sensitivity and specificity.

Basic Information

Product Name	4-Amino-2,3,5,6-Tetradeuterio-n-(6-Methoxypyrimidin-4-Yl)Benzenesulfonamide
CAS No.	1286538-12-2
Molecular Formula	C11H7D4N5O3S
Molecular Weight	285.33 g/mol
Synonyms	4-Amino-2,3,5,6-tetradeuterio-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide; Deuterated Sulfamethoxazole Intermediate; [2H4]-Labeled Sulfonamide; 4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide-2,3,5,6-d4; Sulfamethoxazole-d4 (Intermediate); Benzenesulfonamide, 4-amino-2,3,5,6-tetradeuterio-N-(6-methoxy-4-pyrimidinyl)-; 1286538-12-2
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high chemical and isotopic purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm structure, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.