Description

Didemethyl Citalopram-D6 Hydrobromide is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy and reliability in quantitative bioanalysis. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) applications, where it compensates for matrix effects and instrument variability. It is an essential tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories involved in drug metabolism and pharmacokinetics (DMPK) studies, therapeutic drug monitoring, and forensic toxicology.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of citalopram and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to support clinical trials and drug development.
• Forensic and Clinical Toxicology: Used in assays to confirm and quantify citalopram exposure in forensic investigations or patient compliance monitoring.
• Drug Metabolism Research: Facilitates the study of citalopram's metabolic pathways and the identification of its demethylated metabolites.
• Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Quality Control in Reference Material Production: Acts as a calibrant or system suitability standard in the production of certified reference materials (CRMs).

Basic Information

Product Name	Didemethyl Citalopram-D6 Hydrobromide
CAS No.	1286427-93-7
Molecular Formula	C20H15D6FN2O•HBr
Molecular Weight	411.33 g/mol (for monohydrobromide salt)
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile-D6 Hydrobromide; Desmethylcitalopram-D6 HBr; Didesmethylcitalopram-D6 Hydrobromide; Citalopram Impurity D-D6 (Hydrobromide); Citalopram N-Desmethyl-D6 Metabolite Hydrobromide; Lundbeck Compound 34,177-D6 HBr; (RS)-1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-phthalancarbonitrile-D6 Hydrobromide
EINECS	Contact for details

Quality Control

Every batch of Didemethyl Citalopram-D6 Hydrobromide is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting requirements of mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay (HPLC), isotopic enrichment (NMR/MS), and impurity profile. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-30°C (59-86°F). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.