Description

tert-Butyl (1R*,4R*)-4-Isobutyramidocyclohexylcarbamate is a high-purity, stereochemically defined chiral building block and advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex bioactive molecules, offering precise structural control for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents, particularly in the areas of peptide mimetics and small molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Serves as a constrained scaffold for developing novel peptide-like compounds with enhanced metabolic stability.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Asymmetric Synthesis: Employed as a building block requiring specific (1R*,4R*) stereochemistry for constructing complex chiral targets.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and synthetic chemistry.

Basic Information

Product Name	tert-Butyl (1R*,4R*)-4-Isobutyramidocyclohexylcarbamate
CAS No.	1286275-29-3
Molecular Formula	C15H28N2O3
Molecular Weight	284.40 g/mol
Synonyms	tert-Butyl N-[(1R,4R)-4-(2-methylpropanamido)cyclohexyl]carbamate; (1R,4R)-4-[(tert-Butoxycarbonyl)amino]cyclohexyl isobutyramide; (1R,4R)-N-(tert-Butoxycarbonyl)-4-isobutyramidocyclohexylamine; Boc-(1R,4R)-4-Aminocyclohexyl isobutyramide; (1R,4R)-4-(Boc-amino)cyclohexyl isobutyramide; (1R,4R)-4-Isobutyramidocyclohexylcarbamic acid tert-butyl ester; CAS 1286275-29-3
EINECS	Contact for details

Quality Control

Our tert-Butyl (1R*,4R*)-4-Isobutyramidocyclohexylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.