Description

tert-Butyl (1R*,4R*)-4-(2-Nitrobenzylamino)Cyclohexylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where precise molecular configuration is essential for biological activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds due to its defined stereochemistry and functional groups.
• Process Development & Scale-up: Serves as a critical intermediate for developing and optimizing robust, scalable manufacturing routes for APIs under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, non-commercial APIs for clinical trials.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis projects and the development of new catalytic or asymmetric methodologies.

Basic Information

Product Name	tert-Butyl (1R*,4R*)-4-(2-Nitrobenzylamino)Cyclohexylcarbamate
CAS No.	1286274-49-4
Molecular Formula	C18H27N3O4
Molecular Weight	349.43 g/mol
Synonyms	tert-Butyl N-[(1R,4R)-4-[(2-nitrophenyl)methylamino]cyclohexyl]carbamate; (1R,4R)-tert-Butyl 4-((2-nitrobenzyl)amino)cyclohexylcarbamate; 4-((2-Nitrobenzyl)amino)cyclohexylcarbamic Acid tert-Butyl Ester (1R,4R)-isomer; BOC-(1R,4R)-4-((2-Nitrobenzyl)amino)cyclohexylamine; (1R,4R)-N-Boc-4-((2-nitrobenzyl)amino)cyclohexanamine
EINECS	Contact for details

Quality Control

Our tert-Butyl (1R*,4R*)-4-(2-Nitrobenzylamino)Cyclohexylcarbamate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We adhere to industry best practices and can support development with specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.