Description

tert-Butyl (1R*,4R*)-4-(Picolinamido)Cyclohexylcarbamate is a high-purity, stereochemically defined organic intermediate of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel therapeutic agents, particularly in the field of small molecule drug discovery. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in the construction of molecular scaffolds targeting various protease enzymes.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in mechanism-of-action and target identification studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Peptidomimetic Development: Integral for creating stable, bioavailable analogs of peptide-based therapeutics.
• Custom Synthesis Projects: Supplied to contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis programs.

Basic Information

Product Name	tert-Butyl (1R*,4R*)-4-(Picolinamido)Cyclohexylcarbamate
CAS No.	1286273-93-5
Molecular Formula	C17H25N3O3
Molecular Weight	319.40 g/mol
Synonyms	tert-Butyl N-[(1R,4R)-4-(pyridine-2-carboxamido)cyclohexyl]carbamate; (1R,4R)-N1-(tert-Butoxycarbonyl)-N4-(picolinoyl)cyclohexane-1,4-diamine; 4-(Picolinamido)Cyclohexylcarbamic Acid tert-Butyl Ester (1R,4R)-isomer; BOC-(1R,4R)-4-(Picolinamido)Cyclohexylamine; (1R,4R)-tert-Butyl 4-(picolinamido)cyclohexylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl (1R*,4R*)-4-(Picolinamido)Cyclohexylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.