Description

tert-Butyl (1R*,4R*)-4-[(Pyridin-2-Ylmethyl)Amino]Cyclohexylcarbamate is a sophisticated chiral amine derivative and a key pharmaceutical intermediate. This compound matters for its role in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific stereochemistry and protected functional groups are critical for downstream reactions. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring high-purity, structurally defined building blocks.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) or anti-infective targets.
• Chiral Ligand Precursor: Serves as a starting material for the development of asymmetric catalysts used in enantioselective synthesis.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Peptidomimetic Synthesis: The carbamate-protected cyclohexylamine scaffold is valuable for creating conformationally constrained peptide analogs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl (1R*,4R*)-4-[(Pyridin-2-Ylmethyl)Amino]Cyclohexylcarbamate
CAS No.	1286273-76-4
Molecular Formula	C18H29N3O2
Molecular Weight	319.45 g/mol
Synonyms	tert-Butyl N-[(1R,4R)-4-[(pyridin-2-ylmethyl)amino]cyclohexyl]carbamate; (1R,4R)-4-[(2-Pyridylmethyl)amino]cyclohexylcarbamic acid tert-butyl ester; tert-Butyl ((1R,4R)-4-((pyridin-2-ylmethyl)amino)cyclohexyl)carbamate; Boc-4-[(2-Picolyl)amino]-(1R,4R)-cyclohexylamine; (1R*,4R*)-N-Boc-4-[(2-Pyridylmethyl)amino]cyclohexylamine; trans-tert-Butyl 4-((pyridin-2-ylmethyl)amino)cyclohexylcarbamate; CAS 1286273-76-4
EINECS	Contact for details

Quality Control

Our tert-Butyl (1R*,4R*)-4-[(Pyridin-2-Ylmethyl)Amino]Cyclohexylcarbamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.