Description

tert-Butyl 1-(2-Fluoro-4-Methylbenzyl)Piperidin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine carbamate structure. This compound is of significant value in modern organic synthesis, serving as a critical building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules for therapeutic applications, including potential candidates in neurological and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly those targeting specific receptor sites.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes to construct the core scaffold of potential therapeutic agents.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the pharmacological profile of lead compounds.
• Process Chemistry Development: Serves as a standard or starting material for scaling up and optimizing synthetic pathways in pilot and commercial production.
• Bioconjugation & Prodrug Development: The carbamate and piperidine functionalities make it suitable for designing prodrugs or conjugates to enhance drug delivery and bioavailability.

Basic Information

Product Name	tert-Butyl 1-(2-Fluoro-4-Methylbenzyl)Piperidin-4-Ylcarbamate
CAS No.	1286263-56-6
Molecular Formula	C18H27FN2O2
Molecular Weight	322.42 g/mol
Synonyms	1-(2-Fluoro-4-methylbenzyl)piperidin-4-amine, N-Boc derivative; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-[(2-fluoro-4-methylphenyl)methyl]piperidine; tert-Butyl N-[1-[(2-fluoro-4-methylphenyl)methyl]piperidin-4-yl]carbamate; 1-(2-Fluoro-4-methylbenzyl)-4-[(tert-butoxycarbonyl)amino]piperidine; BOC-4-Amino-1-(2-fluoro-4-methylbenzyl)piperidine; N-Boc-1-(2-Fluoro-4-methylbenzyl)piperidin-4-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(2-Fluoro-4-Methylbenzyl)Piperidin-4-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.