Description

(R)-1-(3-Aminopyrrolidin-1-Yl)-2,2-Dimethylpropan-1-One is a high-purity chiral building block and advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its value lies in its well-defined stereochemistry and functionalized pyrrolidine core, which are critical for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular targeting.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to introduce the (R)-configured 3-aminopyrrolidine moiety into target molecules.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in fine chemical synthesis.
• Peptidomimetic Research: Incorporated into the design of peptidomimetics and protease inhibitors due to its amine-functionalized heterocyclic structure.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Scale-up Process Development: Supplied for process optimization and kilogram-scale production under current Good Manufacturing Practice (cGMP) guidelines for clinical trial material.

Basic Information

Product Name	(R)-1-(3-Aminopyrrolidin-1-Yl)-2,2-Dimethylpropan-1-One
CAS No.	1286209-20-8
Molecular Formula	C9H18N2O
Molecular Weight	170.26 g/mol
Synonyms	(R)-1-(3-Aminopyrrolidin-1-yl)-2,2-dimethylpropan-1-one; (R)-3-Amino-1-pivaloylpyrrolidine; (R)-1-Pivaloyl-3-aminopyrrolidine; (R)-N-(1-Pivaloylpyrrolidin-3-yl)amine; (R)-1-(3-Amino-1-pyrrolidinyl)-2,2-dimethyl-1-propanone; Pivaloyl-(R)-3-aminopyrrolidine; (R)-APAP; (R)-3-AP
EINECS	Contact for details

Quality Control

Our (R)-1-(3-Aminopyrrolidin-1-Yl)-2,2-Dimethylpropan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development from research to commercial scale with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.