Description

(S)-tert-Butyl 1-(2-Methoxybenzyl)Pyrrolidin-3-Ylcarbamate CAS NO 1286209-04-8 is a high-purity chiral intermediate and building block of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry and protected amine functionality, which are critical for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development and scale-up of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Used as a building block to introduce the (S)-configured pyrrolidine moiety into larger molecular architectures.
• Process Chemistry & Scale-up: Serves in the development of robust, scalable synthetic routes for GMP manufacturing of APIs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	(S)-tert-Butyl 1-(2-Methoxybenzyl)Pyrrolidin-3-Ylcarbamate
CAS No.	1286209-04-8
Molecular Formula	C18H28N2O3
Molecular Weight	320.43 g/mol
Synonyms	(S)-tert-Butyl (1-(2-methoxybenzyl)pyrrolidin-3-yl)carbamate; (S)-1-(2-Methoxybenzyl)-3-((tert-butoxycarbonyl)amino)pyrrolidine; tert-Butyl N-[(3S)-1-[(2-methoxyphenyl)methyl]pyrrolidin-3-yl]carbamate; (S)-Boc-1-(2-Methoxybenzyl)-3-aminopyrrolidine; (S)-1-(2-Methoxybenzyl)pyrrolidin-3-yl-carbamic acid tert-butyl ester; (S)-3-(Boc-amino)-1-(2-methoxybenzyl)pyrrolidine; (S)-tert-Butyl 1-(2-Methoxybenzyl)-3-aminopyrrolidine-1-carboxylate (common misnomer); 1286209-04-8
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 1-(2-Methoxybenzyl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support development and commercial projects with specifications tailored to meet GMP, ICH Q7, and other relevant regulatory guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.