Description

(R)-tert-Butyl 1-Picolinoylpyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of advanced drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Serves as a core structural component in the development of protease inhibitors for therapeutic applications.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-tert-Butyl 1-Picolinoylpyrrolidin-3-Ylcarbamate
CAS No.	1286207-97-3
Molecular Formula	C15H21N3O3
Molecular Weight	291.35 g/mol
Synonyms	(R)-tert-Butyl (1-(picolinoyl)pyrrolidin-3-yl)carbamate; tert-Butyl N-[(3R)-1-(pyridine-2-carbonyl)pyrrolidin-3-yl]carbamate; (R)-1-Picolinoylpyrrolidin-3-yl-carbamic Acid tert-Butyl Ester; Boc-Pyrrolidine(3R)-Picolinamide; (S)-tert-Butyl (1-(picolinoyl)pyrrolidin-3-yl)carbamate (Enantiomer); (R)-3-((tert-Butoxycarbonyl)amino)-1-(picolinoyl)pyrrolidine; CAS 1286207-97-3
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-Picolinoylpyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.