Description

(R)-tert-Butyl 3-(4-Amino-2-Fluorophenoxy)Pyrrolidine-1-Carboxylate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for constructing complex, biologically active molecules, particularly in the development of targeted therapies. This compound is essential for research institutions and manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Kinase Inhibitor Development: Used in the research and production of targeted cancer therapies, such as kinase inhibitors.
• CNS Drug Synthesis: Serves as a precursor in the manufacturing of compounds for treating neurological and psychiatric conditions.
• Preclinical & Clinical Research: Essential material for drug discovery programs, from hit-to-lead optimization through to clinical trial material (CTM) production.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce the desired (R)-configuration into final drug molecules.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for cGMP-compliant production runs.

Basic Information

Product Name	(R)-tert-Butyl 3-(4-Amino-2-Fluorophenoxy)Pyrrolidine-1-Carboxylate
CAS No.	1286207-81-5
Molecular Formula	C15H21FN2O3
Molecular Weight	296.34 g/mol
Synonyms	1-Boc-3-((4-amino-2-fluorophenoxy))-(R)-pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-(4-amino-2-fluorophenoxy)pyrrolidine; (R)-3-(4-Amino-2-fluorophenoxy)pyrrolidine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R)-3-(4-amino-2-fluorophenoxy)pyrrolidine-1-carboxylate; (R)-N-Boc-3-(4-amino-2-fluorophenoxy)pyrrolidine; BOC-(R)-3-(4-Amino-2-fluorophenoxy)pyrrolidine; (R)-1-Boc-3-(4-amino-2-fluorophenoxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(4-Amino-2-Fluorophenoxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and residual solvent levels to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.