Description

(R)-tert-Butyl 3-Cyclopropaneamidopiperidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key synthon for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) with high efficacy and specificity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of novel therapeutics, particularly in areas like central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of novel drug candidates, especially for neurological and psychiatric targets.
• Asymmetric Synthesis: Used as a building block to introduce the (R)-configured piperidine-cyclopropaneamide moiety into complex molecular architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for potential API manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and intermediate supply.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API production.

Basic Information

Product Name	(R)-tert-Butyl 3-Cyclopropaneamidopiperidine-1-Carboxylate
CAS No.	1286207-31-5
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	1-Boc-3-(cyclopropanecarboxamido)piperidine, (R)-Isomer; tert-Butyl (3R)-3-(cyclopropanecarboxamido)piperidine-1-carboxylate; (R)-1-Boc-3-(cyclopropanecarboxamido)piperidine; (R)-1-N-Boc-3-(cyclopropanecarboxamido)piperidine; (R)-3-(Cyclopropanecarboxamido)piperidine-1-carboxylic acid tert-butyl ester; Boc-3-Cyclopropaneamido-piperidine, (R)- (S)-tert-Butyl 3-((R)-cyclopropanecarboxamido)piperidine-1-carboxylate (check stereochemistry); UNII- Contact for details
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-Cyclopropaneamidopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric purity, to meet the exacting standards required for pharmaceutical R&D and development. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.