Description

(R)-tert-Butyl 1-(4-Bromobenzyl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and cardiovascular drugs. It is essential for medicinal chemistry research, process development, and commercial-scale manufacturing within the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel therapeutic agents, especially in CNS and cardiovascular research.
• Asymmetric Synthesis: Used as a precursor in catalytic asymmetric reactions to construct complex molecular architectures.
• Medicinal Chemistry R&D: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the development and scale-up of robust, cost-effective synthetic routes for API manufacturing.
• Protease Inhibitor Development: Potential building block for inhibitors targeting specific enzymes.
• Custom Synthesis: Starting material for the preparation of specialized compounds for clinical trials and commercial production.

Basic Information

Product Name	(R)-tert-Butyl 1-(4-Bromobenzyl)Pyrrolidin-3-Ylcarbamate
CAS No.	1286207-07-5
Molecular Formula	C16H23BrN2O2
Molecular Weight	355.27 g/mol
Synonyms	(R)-tert-Butyl (1-(4-bromobenzyl)pyrrolidin-3-yl)carbamate; (3R)-1-[(4-Bromophenyl)methyl]-3-pyrrolidinyl carbamic acid 1,1-dimethylethyl ester; tert-Butyl N-[(3R)-1-[(4-bromophenyl)methyl]pyrrolidin-3-yl]carbamate; (R)-Boc-1-(4-Bromobenzyl)-3-aminopyrrolidine; (R)-1-(4-Bromobenzyl)-3-(Boc-amino)pyrrolidine; (R)-N-Boc-1-(4-Bromobenzyl)-3-aminopyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(4-Bromobenzyl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.