Description

Xanax-D5 is a deuterated internal standard of the pharmaceutical compound Alprazolam, specifically designed for analytical and research applications. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and other analytical techniques. It is primarily utilized by analytical laboratories, pharmaceutical researchers, and forensic scientists for method development, quality control, and pharmacokinetic studies.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of Alprazolam in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of Alprazolam.
• Forensic and Clinical Toxicology: Enables accurate measurement of Alprazolam levels in forensic investigations and clinical overdose cases, ensuring legally defensible and medically accurate results.
• Method Development and Validation: Provides a stable isotopic reference for developing, optimizing, and validating new analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Acts as a reference standard for in-process testing and final product release to ensure batch consistency and purity of Alprazolam-based medications.
• Stable Isotope Labeling Studies: Facilitates research into metabolic pathways and environmental fate of benzodiazepine compounds.

Basic Information

Product Name	Xanax-D5
CAS No.	1286073-82-2
Molecular Formula	C17H8D5ClN4
Molecular Weight	313.78 g/mol (for deuterated form)
Synonyms	Alprazolam-d5; 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-d5; Alprazolam (phenyl-d5); Deuterated Alprazolam; Xanax Internal Standard; Alprazolam D5; Alprazolam (methyl-d3, phenyl-d2)
EINECS	Contact for details

Quality Control

Every batch of Xanax-D5 is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.