Description

Rac-Cevimeline-D4 Hcl is a deuterated isotopologue of the muscarinic acetylcholine receptor agonist cevimeline, specifically labeled with four deuterium atoms. This compound is of significant value for pharmaceutical research and development, serving as a critical internal standard for precise quantitative analysis in bioanalytical studies. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require high-fidelity analytical standards to ensure accurate pharmacokinetic and metabolic profiling.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and GC-MS bioanalysis for quantifying cevimeline and its metabolites.
• Supporting Drug Metabolism and Pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion of cevimeline.
• Facilitating Stable Isotope Dilution Assays to achieve superior accuracy and precision in quantitative analytical methods.
• Use in Pharmaceutical R&D for method development, validation, and quality control of active pharmaceutical ingredients (APIs).
• Application in Clinical Research for monitoring drug levels in biological matrices during clinical trials.
• Reference material for Forensic and Anti-Doping Analysis where precise identification and quantification are required.

Basic Information

Product Name	Rac-Cevimeline-D4 Hcl
CAS No.	1286024-71-2
Molecular Formula	C10H13D4N2OS • HCl
Molecular Weight	244.78 g/mol (for free base C10H13D4N2OS)
Synonyms	(±)-Cevimeline-d4 Hydrochloride
Racemic Cevimeline-d4 HCl
AF102B-d4
(±)-cis-2-Methylspiro(1-azabicyclo[2.2.2]octane-3,5'-oxazolidin)-2'-one-d4 Hydrochloride
SNI-2011-d4 Hydrochloride
Deuterium Labeled Cevimeline HCl
2-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one-d4 Hydrochloride (racemic)
EINECS	Contact for details

Quality Control

Our deuterated analytical standards are produced under strict quality management to ensure the highest isotopic purity and chemical integrity, which is critical for reliable analytical results. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98% D), chemical purity (by HPLC), and confirming structural identity. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.