Description

10-[3-[2,2,3,3,5,5,6,6-Octadeuterio-4-(2-Hydroxyethyl)Piperazin-1-Yl]Propyl]-8-(Trifluoromethyl)Phenothiazin-3-Ol is a deuterated derivative of a phenothiazine-based compound, designed for advanced research and development applications. This high-purity chemical is critical for studies requiring stable isotope labeling, particularly in pharmacokinetics, metabolism, and tracer analysis. It is primarily utilized by pharmaceutical R&D laboratories, analytical service providers, and academic institutions focused on drug discovery and development.

Application

• Internal Standard for LC-MS/MS: Serves as a deuterated internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical methods, enhancing accuracy in pharmacokinetic studies.
• Metabolite Identification & Tracing: Used in drug metabolism and disposition (DMPK) studies to track and identify metabolites using mass spectrometry.
• Pharmaceutical Reference Standard: Acts as a certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision quantitative analysis to correct for matrix effects and instrument variability.
• Proteomics & Biomarker Research: Potential application in chemical proteomics and as a tool compound for investigating biological pathways.
• Preclinical & Clinical Research: Supports non-clinical and clinical trial studies requiring stable isotope-labeled compounds for reliable data.

Basic Information

Product Name	10-[3-[2,2,3,3,5,5,6,6-Octadeuterio-4-(2-Hydroxyethyl)Piperazin-1-Yl]Propyl]-8-(Trifluoromethyl)Phenothiazin-3-Ol
CAS No.	1285980-02-0
Molecular Formula	C22H21D8F3N3O2S
Molecular Weight	473.60 g/mol (approx.)
Synonyms	Deuterated Methylene Blue Derivative; 8-(Trifluoromethyl)-10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazin-3-ol-d8; Phenothiazin-3-ol, 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-8-(trifluoromethyl)-, octadeuterio derivative; Deuterated Azure B derivative; D8-Labeled Phenothiazine Derivative; CAS 1285980-02-0
EINECS	Contact for details

Quality Control

Our 10-[3-[2,2,3,3,5,5,6,6-Octadeuterio-4-(2-Hydroxyethyl)Piperazin-1-Yl]Propyl]-8-(Trifluoromethyl)Phenothiazin-3-Ol is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ²H), HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and stored in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Dark blue to green solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (¹H, ¹³C, ²H)
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.