Description

Cisapride-13C,D3 CAS NO 1285970-69-5 is a stable isotope-labeled analog of the gastroprokinetic agent cisapride, specifically enriched with carbon-13 and deuterium. This compound is an essential internal standard for the precise and accurate quantification of cisapride in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical method development, pharmacokinetic studies, and drug metabolism research. The use of this isotopically labeled standard is critical for ensuring data integrity and regulatory compliance in quantitative mass spectrometry.

Application

• Internal Standard for Quantitative Bioanalysis: Serves as the critical reference compound in the development and validation of LC-MS/MS methods for quantifying cisapride in plasma, serum, and other biological fluids.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling and Degradation Studies: Used as a marker in stability-indicating methods to identify and quantify related substances and degradation products.
• Forensic and Toxicological Analysis: Supports accurate measurement of cisapride levels in forensic investigations or toxicology screenings.
• Reference Material for Certified Standards: Acts as a high-purity starting material for the preparation of certified reference materials (CRMs) and calibration standards.

Basic Information

Product Name	Cisapride-13C,D3
CAS No.	1285970-69-5
Molecular Formula	C23H26D3FN3O4-13C
Molecular Weight	~ 466.5 g/mol
Synonyms	Cisapride-13C,d3; 4-Amino-5-chloro-N-[1-[3-(13C)cyano-3,3-dideuteropropoxy]-4-fluorobenzyl]-2-methoxybenzamide; 4-Amino-5-chloro-N-{1-[3-(cyano-13C)-3,3-dideuteropropoxy]-4-fluorobenzyl}-2-methoxybenzamide; Isotopically Labeled Cisapride; Cisapride Internal Standard; [13C,D3]-Cisapride; Prepulsid-13C,D3 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Cisapride-13C,D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC assay, NMR for isotopic enrichment verification, and LC-MS for identity confirmation. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for purity, isotopic abundance, and solvent residues. Our quality commitment supports compliance with the stringent requirements of GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure and isotopic pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.