Description

Reboxetine-D5, Mesylate is a deuterated internal standard of the selective norepinephrine reuptake inhibitor (NRI) Reboxetine, labeled with five deuterium atoms and provided as the mesylate salt. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory agencies involved in the development and quality control of antidepressant therapies.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of Reboxetine in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Used as a reference in mass spectrometry to distinguish drug-derived metabolites from endogenous compounds.
• Method Development & Validation: Critical for developing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control & Assurance: Supports in-house QC testing of active pharmaceutical ingredients (APIs) and finished drug products for potency and purity.
• Doping Control & Forensic Analysis: Acts as a reference standard in forensic toxicology for the detection of Reboxetine.

Basic Information

Product Name	Reboxetine-D5, Mesylate
CAS No.	1285918-53-7
Molecular Formula	C19H18D5NO4S
Molecular Weight	Contact for details
Synonyms	(2R,2S)-2-[(R,S)-α-[(2-Ethoxyphenoxy)benzyl]morpholine-d5 Methanesulfonate; Reboxetine-d5 Mesylate; Reboxetine (phenyl-d5) Mesylate; (±)-2-[(α-(2-Ethoxyphenoxy)benzyl]morpholine-d5 Methanesulfonate; FCE 20124-d5 Mesylate; Edronax-d5 Mesylate
EINECS	Contact for details

Quality Control

Our Reboxetine-D5, Mesylate is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the high standards required for use as an internal standard. Each batch is characterized by advanced techniques including NMR, HPLC, and mass spectrometry to confirm chemical identity, isotopic purity (D5), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D5)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.