Description

Febuxostat-D7 is a deuterated analog of the xanthine oxidase inhibitor Febuxostat, specifically labeled with seven deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and clinical research for gout and hyperuricemia treatments.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of Febuxostat in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug and its metabolites.
• Clinical Research & Bioequivalence Studies: Enables accurate measurement of Febuxostat concentration in human clinical trials and bioequivalence testing for generic drug development.
• Pharmaceutical Quality Control: Supports analytical method development and validation for drug substance and drug product testing in GMP environments.
• Forensic and Doping Analysis: Potential use in specialized analytical protocols for forensic toxicology or anti-doping control where precise drug level quantification is required.

Basic Information

Product Name	Febuxostat-D7
CAS No.	1285539-74-3
Molecular Formula	C16H9D7N2O3S
Molecular Weight	324.40 g/mol
Synonyms	2-[(3-Cyano-4-isobutoxyphenyl)-D7]-4-methylthiazole-5-carboxylic Acid; Febuxostat (D7); Febuxostat-d7; Febuxostat Internal Standard; TMX-67-D7; Uloric-D7; TEI-6720-D7; Deuterated Febuxostat
EINECS	Contact for details

Quality Control

Our Febuxostat-D7 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (≥98 atom % D), chemical purity (by HPLC), and confirmation of structure. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee reliable and reproducible performance in sensitive mass spectrometry applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.