Description

3-(2-(2-(Chloromethoxy)Ethoxy)Ethoxy)Prop-1-Yne is a specialized alkyne-functionalized PEG derivative featuring a chloromethyl ether linker. This compound matters as a versatile and reactive building block for click chemistry and bioconjugation, enabling the precise modification of polymers, surfaces, and biomolecules. It is primarily needed by researchers and manufacturers in pharmaceutical development, advanced material science, and polymer chemistry for creating functionalized carriers, probes, and cross-linked networks.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for antibody-drug conjugates (ADCs) and targeted drug delivery systems via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Polymer Functionalization: Used to introduce alkyne handles onto polymer backbones (e.g., PEG, PLGA) for subsequent grafting or cross-linking reactions.
• Surface Modification: Enables the covalent attachment of functional layers to glass, silicon, or metal oxide surfaces for biosensor and microarray fabrication.
• Material Science Research: Acts as a cross-linker or chain extender in the synthesis of novel hydrogels and smart materials with tailored properties.
• Bioconjugation Probe: Facilitates the labeling of peptides, proteins, and oligonucleotides with fluorescent dyes or other reporter molecules.
• Ligand Synthesis: Employed in the development of chemical probes and ligands for biological target identification and validation.

Basic Information

Product Name	3-(2-(2-(Chloromethoxy)Ethoxy)Ethoxy)Prop-1-Yne
CAS No.	1281695-01-9
Molecular Formula	C8H13ClO3
Molecular Weight	192.64 g/mol
Synonyms	Propargyl-PEG2-chloromethyl ether; 2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxymethyl chloride; 3,6,9-Trioxa-11-dodecyn-1-yl chloromethyl ether; Chloromethyl ether PEG2 alkyne; Alkyne-PEG2-CH2Cl; Propargyl PEG2 chloromethyl ether; 1-Chloromethyl-2,5,8-trioxa-10-undecyne; PEG2 alkyne chloromethyl ether
EINECS	Contact for details

Quality Control

Our 3-(2-(2-(Chloromethoxy)Ethoxy)Ethoxy)Prop-1-Yne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and reactive functional groups, it is recommended to store under an inert atmosphere for long-term stability and to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.