Description

Benazepril-D5 is a stable isotope-labeled analog of the active pharmaceutical ingredient Benazepril, specifically deuterated at five positions. This high-purity reference standard is essential for ensuring accurate and reliable quantitative analysis in complex biological matrices. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Benazepril and its metabolites in plasma, serum, and urine using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Bioanalytical Method Development: Used in the development and validation of robust, GLP-compliant analytical methods for clinical and preclinical studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in study subjects.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles, aiding in understanding the metabolic pathways of Benazepril.
• Quality Control in Manufacturing: Acts as a reference material for quality control laboratories to verify the identity and purity of Benazepril API batches.
• Forensic and Doping Analysis: Provides a definitive reference for confirmatory testing in forensic toxicology and anti-doping control.

Basic Information

Product Name	Benazepril-D5
CAS No.	1279200-03-1
Molecular Formula	C24H23D5N2O5
Molecular Weight	~429.52 g/mol
Synonyms	Benazepril-d5; (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid-d5; 1H-1-Benzazepine-1-acetic acid-d5, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-; Deuterated Benazepril; Benazepril (phenyl-d5); Stable Isotope Labeled Benazepril; CGS-14824A-d5
EINECS	Contact for details

Quality Control

Our Benazepril-D5 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity, chemical purity, and identity confirmation. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.