Description

Ribavirin-13C2 is a stable isotope-labeled analog of the broad-spectrum antiviral nucleoside Ribavirin, specifically labeled with two carbon-13 atoms. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is critically needed by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in the development and bioanalysis of antiviral therapeutics.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of Ribavirin in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Metabolite Identification & Profiling: Aids in the detection and structural elucidation of Ribavirin metabolites using stable isotope dilution techniques.
• Method Development & Validation: Used to develop, optimize, and validate robust analytical assays in compliance with GLP and FDA/EMA guidelines.
• Drug Metabolism Research: Facilitates in-depth studies on the metabolic pathways and enzymatic interactions of antiviral agents.
• Quality Control in Manufacturing: Can be employed in impurity profiling and assay verification during the production of Ribavirin active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Ribavirin-13C2
CAS No.	1279035-36-7
Molecular Formula	C713C2H12N4O5
Molecular Weight	248.19 g/mol (for 13C2 labeled form)
Synonyms	1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide-13C2; Virazole-13C2; ICN-1229-13C2; RTCA-13C2; Ribavirin (13C2); Ribavirin-13C2; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide-13C2
EINECS	Contact for details

Quality Control

Our Ribavirin-13C2 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch undergoes rigorous testing, including HPLC assay, isotopic enrichment analysis by MS, and identification by NMR and IR. Certificates of Analysis (COA) detailing all specifications, including chemical purity (typically ≥98%) and isotopic purity (≥99 atom % 13C), are provided to guarantee traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99 atom % 13C
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.