Description

Raloxifene-4'-Glucuronide_D4 is a deuterium-labeled internal standard critical for quantitative bioanalytical research. This high-purity reference material is essential for ensuring the accuracy and precision of mass spectrometry-based assays. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced pharmacokinetic, metabolic, and clinical studies of the selective estrogen receptor modulator (SERM) raloxifene.

Application

• LC-MS/MS Internal Standard: Serves as a deuterated internal standard for the precise quantification of Raloxifene-4'-Glucuronide and its parent drug in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug and metabolite concentrations over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Metabolite Profiling & Identification: Aids in the structural confirmation and quantification of glucuronidated metabolites during drug metabolism and pharmacodynamics (DMPK) research.
• Bioequivalence & Clinical Trial Support: Provides reliable data for bioanalytical method development and validation in support of clinical trials and regulatory submissions.
• Forensic & Doping Control Analysis: Used in specialized testing laboratories for the accurate detection and quantification of SERMs in forensic or anti-doping contexts.

Basic Information

Product Name	Raloxifene-4'-Glucuronide_D4
CAS No.	1279033-52-1
Molecular Formula	C32H31D4NO11S
Molecular Weight	~653.7 g/mol
Synonyms	Raloxifene D4-4'-Glucuronide; Raloxifene-4'-β-D-Glucuronide-d4; 6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene-4'-β-D-Glucuronide-d4; LY353381-4'-Glucuronide-d4; Keoxifene-4'-Glucuronide-d4; EVISTA® Metabolite-d4 (Deuterated); [2-(4-Hydroxyphenyl)-6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-1-benzothiophen-4-yl] β-D-Glucopyranosiduronic Acid-d4
EINECS	Contact for details

Quality Control

Every batch of Raloxifene-4'-Glucuronide_D4 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles. Our quality commitment ensures compliance with the standards expected for reference materials and internal standards used in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.