Description

Valacyclovir-D8 HCl (L-Valine-D8) is a deuterated isotopologue of the antiviral prodrug valacyclovir, specifically labeled with eight deuterium atoms on the L-valine moiety. This high-purity stable isotope-labeled compound is critical for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers focused on antiviral drug development and therapeutic drug monitoring.

Application

• LC-MS/MS Internal Standard: Primary application as a certified reference material for the precise quantification of valacyclovir and its metabolite acyclovir in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• DMPK (Drug Metabolism and Pharmacokinetics): Used in mass spectrometry-based assays to study the metabolic pathways and stability of antiviral agents.
• Regulatory Submission Support: Provides the method validation data required for compliance with FDA, EMA, and other global health authority guidelines for bioanalytical method validation.
• Diagnostic Assay Development: Serves as a key component in the development of high-sensitivity in-vitro diagnostic (IVD) tests for antiviral therapy management.
• Stable Isotope Labeling Research: Used as a tracer in advanced metabolic flux analysis and proteomics research.

Basic Information

Item	Detail
Product Name	Valacyclovir-D8 HCl (L-Valine-D8)
CAS No.	1279033-32-7
Molecular Formula	C13H12D8ClN6O4
Molecular Weight	Contact for details
Synonyms	L-Valine-2H8 Valacyclovir Hydrochloride; Valacyclovir-d8 hydrochloride; 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl (2S)-3-methyl-2-[(pentanoyl-2H8)amino]butanoate hydrochloride; Valtrex-d8 HCl; BW256U87-d8; Zelitrex-d8
EINECS	Contact for details

Quality Control

Every batch of Valacyclovir-D8 HCl is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and all relevant analytical data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.