Description

Benazeprilat-D5 is a high-purity, stable isotope-labeled analog of the active metabolite of the antihypertensive drug benazepril. This deuterated compound is an essential internal standard for achieving precise and reliable quantification in bioanalytical studies, ensuring data integrity for regulatory submissions. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic, metabolism, and clinical research.

Application

• Internal Standard for LC-MS/MS quantification of benazeprilat in biological matrices (plasma, serum, urine).
• Metabolite profiling and pharmacokinetic (PK) studies in drug development.
• Bioequivalence and bioavailability studies for generic pharmaceutical development.
• Use in high-throughput clinical testing and therapeutic drug monitoring (TDM) method development.
• Stable isotope dilution analysis for enhanced accuracy in complex sample analysis.
• Research into the metabolic pathways and clearance mechanisms of ACE inhibitors.

Basic Information

Product Name	Benazeprilat-D5
CAS No.	1279033-05-4
Molecular Formula	C24H23D5N2O5
Molecular Weight	~429.51 g/mol
Synonyms	(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid-D5; Benazeprilat-d5; CGS 14831-d5; CGS-14831-d5; (S,S,S)-Benazeprilat-d5; Deuterated Benazeprilat; [2,3,4,5,6-2H5]Benazeprilat
EINECS	Contact for details

Quality Control

Our Benazeprilat-D5 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and purity by HPLC. We adhere to cGMP principles for pharmaceutical reference standards, ensuring traceability and consistency for our global clientele in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Chemical Purity (HPLC, area %)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.