Description

Galanthamine-o-Methyl-D3 CAS NO 1279031-09-2 is a deuterated isotopologue of galanthamine, a natural alkaloid, specifically labeled on the o-methyl group. This compound serves as a critical internal standard and reference material in quantitative bioanalytical methods, ensuring precise and accurate measurement of galanthamine and its metabolites in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and the development of galanthamine-based therapeutics for neurological conditions.

Application

• Internal Standard for LC-MS/MS: Essential for the quantitative analysis of galanthamine in plasma, serum, and tissue samples using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track the parent drug and its metabolic pathways.
• Bioanalytical Method Development and Validation: A key component in developing robust, regulatory-compliant (FDA, EMA) assay protocols for clinical and non-clinical trials.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradants in active pharmaceutical ingredient (API) batches.
• Isotope Dilution Mass Spectrometry (IDMS): Employed as a spike-in standard for high-precision quantification, correcting for matrix effects and instrument variability.
• Neurological Research: Supports fundamental research into the mechanisms of acetylcholinesterase inhibition and the development of treatments for Alzheimer's disease and other cognitive disorders.

Basic Information

Product Name	Galanthamine-o-Methyl-D3
CAS No.	1279031-09-2
Molecular Formula	C17H18D3NO3
Molecular Weight	290.38 g/mol
Synonyms	Galanthamine O-Methyl-d3; (4aS,6R,8aS)-11-Methyl-6-(trideuteriomethoxy)-4a,5,9,10,11,12-hexahydro-3H-6,8a-methanofuro[3a,3,2-ef][2]benzazocin-3-ol; Galantamine O-Methyl-d3; Deuterated Galanthamine; Galanthamine-d3 (O-methyl); Galanthamine Internal Standard; Nivalin-d3 (O-methyl derivative)
EINECS	Contact for details

Quality Control

Every batch of Galanthamine-o-Methyl-D3 is manufactured under controlled conditions and undergoes comprehensive analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocol includes chromatographic purity (HPLC), confirmation of chemical structure (NMR, MS), and verification of deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. We support compliance with cGMP and ICH guidelines for reference standards used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.