Description

Fmoc-(2S,3S)-2-Amino-3-Methoxybutanoic Acid CAS NO 1279029-70-7 is a high-purity, non-proteinogenic amino acid derivative featuring a stereochemically defined methoxy-substituted side chain. This compound is critically important as a specialized building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique conformational and functional properties. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced drug discovery, particularly for developing novel therapeutic peptides and constrained analogs.

Application

• Peptide Synthesis: A key protected amino acid for Fmoc-based solid-phase peptide synthesis (SPPS) to incorporate a conformationally constrained, methoxy-bearing residue.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Peptidomimetic Design: Serves as a crucial scaffold for creating peptidomimetics with enhanced metabolic stability, bioavailability, and target selectivity.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides used as tools to study protein-protein interactions and biological pathways.
• Material Science: Potential use in synthesizing functionalized polymers or biomaterials with specific chiral and structural properties.

Basic Information

Product Name	Fmoc-(2S,3S)-2-Amino-3-Methoxybutanoic Acid
CAS No.	1279029-70-7
Molecular Formula	C₂₀H₂₁NO₅
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-(2S,3S)-2-Amino-3-methoxybutyric Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-L-threonine; Fmoc-L-threonine(OMe)-OH; Fmoc-3-OMe-Thr-OH; (2S,3S)-2-[(9-Fluorenylmethoxycarbonyl)amino]-3-methoxybutanoic acid; Nα-Fmoc-O-methyl-L-threonine; N-Fmoc-3-methoxy-L-threonine
EINECS	Contact for details

Quality Control

Our Fmoc-(2S,3S)-2-Amino-3-Methoxybutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be stored away from light as indicated. For long-term storage, consider desiccated conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.