Description

L-Proline, 4-[[(Phenylmethoxy)Carbonyl]Amino]-, Methyl Ester is a protected amino acid derivative, specifically a Cbz-protected proline methyl ester, which serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity, structurally defined intermediates to ensure the fidelity of complex molecular assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the synthesis of peptides, peptidomimetics, and other bioactive molecules where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected proline residue to construct peptide chains with specific conformational properties.
• Proteomics Research: Employed in the design and synthesis of peptide probes, substrates, and inhibitors for enzymatic studies and biochemical assays.
• Chemical Biology: Serves as a building block for creating labeled peptides, molecular tools, and conjugates for studying protein-protein interactions and cellular processes.
• Process Development: Utilized in scaling up synthetic routes for peptide drugs and other complex organic molecules under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	L-Proline, 4-[[(Phenylmethoxy)Carbonyl]Amino]-, Methyl Ester
CAS No.	1279026-84-4
Molecular Formula	C15H19N2O4+
Molecular Weight	291.32 g/mol
Synonyms	(2S)-1-[(Benzyloxy)carbonyl]-4-aminopyrrolidine-2-carboxylic acid methyl ester; Methyl N-Cbz-4-amino-L-prolinate; Methyl (2S)-1-{[(benzyloxy)carbonyl]amino}-4-aminopyrrolidine-2-carboxylate; Nα-Cbz-4-amino-L-proline methyl ester; L-Proline, 4-amino-, 1-[(phenylmethoxy)carbonyl]-, methyl ester; Cbz-4-NH2-Pro-OMe; Z-4-Amino-Pro-OMe
EINECS	Contact for details

Quality Control

Our L-Proline, 4-[[(Phenylmethoxy)Carbonyl]Amino]-, Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.