Description

Benazepril-D5 Hydrochloride is a high-purity, isotopically labeled internal standard essential for precise quantitative analysis in pharmaceutical research and development. This deuterated compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) applications, where it provides critical correction for analyte loss during sample preparation and ionization. It is a vital tool for analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and academic institutions focusing on the metabolism, pharmacokinetics, and bioanalytical studies of the antihypertensive drug Benazepril.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard (SIL-IS) for the accurate LC-MS/MS quantification of Benazepril and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Critical for developing and validating robust, regulatory-compliant (FDA, EMA) bioanalytical methods in Good Laboratory Practice (GLP) environments.
• Doping Control & Forensic Analysis: Used in specialized testing laboratories for the definitive identification and quantification of Benazepril.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product quality control.
• Isotope Dilution Mass Spectrometry (IDMS): Applied in high-accuracy measurement techniques where maximum precision is required.

Basic Information

Product Name	Benazepril-D5 Hydrochloride
CAS No.	1279026-26-4
Molecular Formula	C24H23D5N2O5•HCl
Molecular Weight	466.98 g/mol
Synonyms	(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid-3,3,4,4,5,5-d5 Hydrochloride; Benazepril-d5 HCl; 1H-1-Benzazepine-1-acetic acid, 2,3,4,5-tetrahydro-3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-, (3S)-, hydrochloride, labeled with deuterium; Deuterated Benazepril Hydrochloride; Benazepril Internal Standard; Benazepril-d5 (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Benazepril-D5 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity required for sensitive mass spectrometry applications. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment (D5 content), and purity by HPLC. We support research conducted under GLP and GMP guidelines, and specifications can be aligned with your specific methodological requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D (D5)
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.