Description

(S)-(-)-Carbidopa-D3 is a deuterium-labeled isotopologue of the pharmaceutical agent (S)-Carbidopa, a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of levodopa/carbidopa combination therapies for Parkinson's disease.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of Carbidopa in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Carbidopa.
• Bioequivalence and Clinical Trials: Supports robust analytical method development and validation for clinical studies involving anti-Parkinsonian medications.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of related substances and degradation products in drug substance and product analysis.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies of metabolic pathways and enzymatic processes involving decarboxylase inhibition.

Basic Information

Product Name	(S)-(-)-Carbidopa-D3
CAS No.	1276732-89-8
Molecular Formula	C10H11D3N2O4
Molecular Weight	229.24 g/mol
Synonyms	(2S)-3-(3,4-Dihydroxyphenyl)-2-hydrozino-2-methyl-3,3,3-d3-propanoic Acid; L-α-Hydrazino-3,4-dihydroxy-α-methyl-β,β,β-d3-hydrocinnamic Acid; MK-486-d3; Lodosyn-d3; (S)-Carbidopa-d3; Carbidopa (methyl-d3); Carbidopa-d3 Isotopologue
EINECS	Contact for details

Quality Control

Our (S)-(-)-Carbidopa-D3 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards for reference materials, and specifications can be tailored to meet specific pharmacopeial or internal method requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.