Description

(S)-(-)-Carbidopa-D3 H2O (Ring-D3) is a stable isotope-labeled analog of the pharmaceutical agent Carbidopa, specifically deuterated on the aromatic ring. This high-purity compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and validation of LC-MS/MS assays for levodopa/carbidopa therapies.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a deuterated internal standard for the precise quantification of Carbidopa in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based metabolite screening.
• Method Development and Validation: Serves as a critical reference material for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Used in in-process testing and final product release assays to ensure the quality and consistency of Carbidopa-containing drug products.
• Doping Control Analysis: Potential application in sports anti-doping laboratories for the accurate detection and quantification of prohibited substances.

Basic Information

Item	Detail
Product Name	(S)-(-)-Carbidopa-D3 H2O (Ring-D3)
CAS No.	1276197-58-0
Molecular Formula	C10H11D3N2O4 · H2O
Molecular Weight	244.26 g/mol (anhydrous basis)
Synonyms	Carbidopa-d3; (2S)-3-(3,4-Dihydroxyphenyl-3,5,6-d3)-2-hydrazino-2-methylpropanoic acid monohydrate; L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid-d3 monohydrate; MK-486-d3; Lodosyn-d3; Isotopically Labeled Carbidopa; Carbidopa Internal Standard
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-Carbidopa-D3 H2O (Ring-D3) is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments, including Chemical Purity (HPLC), Isotopic Enrichment (MS), and Structural Confirmation (NMR, IR). Certificates of Analysis (COA) detailing batch-specific results are available upon request and are essential for audit and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	6.0% - 8.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.