Description

(±)-Alfuzosin-D7 Hcl (Tetrahydrofuroyl-D7) is a deuterated internal standard of the α-1 adrenergic receptor antagonist Alfuzosin, specifically labeled on the tetrahydrofuroyl moiety. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical companies and contract research organizations (CROs) for pharmacokinetic studies, drug metabolism investigations, and bioanalytical method validation.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Alfuzosin and its metabolites in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to track the fate of the parent drug molecule in biological systems.
• Method Development and Validation: A key component in developing and validating robust, GLP-compliant bioanalytical methods for clinical and non-clinical trials.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for the pharmaceutical active ingredient.
• Forensic and Doping Control Analysis: Supports the accurate detection and quantification of Alfuzosin in specialized forensic or anti-doping testing protocols.

Basic Information

Item	Detail
Product Name	(±)-Alfuzosin-D7 Hcl (Tetrahydrofuroyl-D7)
CAS No.	1276197-14-8
Molecular Formula	C19H20D7N5O4 • HCl
Molecular Weight	425.96 g/mol (for free base, calculated)
Synonyms	Alfuzosin-d7 Hydrochloride; Alfuzosin (tetrahydrofuroyl-d7) Hydrochloride; N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide-d7 Hydrochloride; Alfuzosin Internal Standard-d7; Alfuzosin IS-d7; Uroxatral-d7 HCl; 1276197-14-8 (CAS)
EINECS	Contact for details

Quality Control

Every batch of (±)-Alfuzosin-D7 Hcl (Tetrahydrofuroyl-D7) is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms to structure
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.