Description

Ethyl 5-(3-Fluorophenyl)-1,2,4-Oxadiazole-3-Carboxylate is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the 1,2,4-oxadiazole pharmacophore with a fluorinated aromatic moiety into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorophenyl-oxadiazole structure can contribute to biological activity and metabolic stability.
• Chemical Biology Probe Development: Serves as a building block for creating fluorescent tags, enzyme inhibitors, or other molecular probes used in biochemical and cellular research.
• Material Science Precursor: Potential intermediate in the synthesis of specialty polymers, liquid crystals, or organic electronic materials that require fluorinated heterocyclic components.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Ethyl 5-(3-Fluorophenyl)-1,2,4-Oxadiazole-3-Carboxylate
CAS No.	1274477-51-8
Molecular Formula	C11H9FN2O3
Molecular Weight	236.20 g/mol
Synonyms	Ethyl 3-fluoro-1,2,4-oxadiazole-5-carboxylate (3-fluorophenyl); 5-(3-Fluorophenyl)-1,2,4-oxadiazole-3-carboxylic acid ethyl ester; 1,2,4-Oxadiazole-3-carboxylic acid, 5-(3-fluorophenyl)-, ethyl ester; Ethyl 5-(m-fluorophenyl)-1,2,4-oxadiazole-3-carboxylate; 3-Fluorophenyl-1,2,4-oxadiazole ethyl carboxylate; 1274477-51-8; Ethyl 5-(3-fluorophenyl)-[1,2,4]oxadiazole-3-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-(3-Fluorophenyl)-1,2,4-Oxadiazole-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.