Description

7-Bromo-5-(trifluoromethyl)-2,3,4-trihydronaphthalen-1-one is a high-purity, advanced pharmaceutical intermediate characterized by its brominated and trifluoromethyl-substituted tetrahydronaphthalenone structure. This compound is of significant commercial importance as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry programs.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the trifluoromethyl and bromine functional groups.
• Material Science: Acts as a monomer or specialty additive in the research of advanced polymers and organic electronic materials.
• Academic & Industrial R&D: Employed in chemical research for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Contract Manufacturing: Supplied to CDMOs for scale-up production under current Good Manufacturing Practice (cGMP) conditions for clinical trial material supply.

Basic Information

Product Name	7-Bromo-5-(trifluoromethyl)-2,3,4-trihydronaphthalen-1-one
CAS No.	1273673-31-6
Molecular Formula	C11H8BrF3O
Molecular Weight	293.08 g/mol
Synonyms	7-Bromo-5-(trifluoromethyl)-1-tetralone; 1-Tetralone, 7-bromo-5-(trifluoromethyl)-; 7-Bromo-5-trifluoromethyl-3,4-dihydro-2H-naphthalen-1-one; 7-Bromo-5-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one; 7-Bromo-5-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-one
EINECS	Contact for details

Quality Control

Our 7-Bromo-5-(trifluoromethyl)-2,3,4-trihydronaphthalen-1-one is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.