Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Hydroxypropanoic Acid Hydrate is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for the controlled introduction of serine residues in solid-phase peptide synthesis (SPPS) methodologies. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions developing novel therapeutic peptides, APIs, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected serine derivative for the sequential assembly of peptide chains on resin supports.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Serves as a precursor for creating peptide conjugates for diagnostic probes, drug delivery systems, and biophysical studies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Institutional Research: Fundamental reagent for studying peptide structure, function, and synthesis protocols in university and government laboratories.
• Custom Oligopeptide Production: Essential raw material for CROs and CDMOs specializing in the manufacture of custom peptides for clients.

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Hydroxypropanoic Acid Hydrate
CAS No.	1272755-68-6
Molecular Formula	C18H17NO6 • xH2O
Molecular Weight	~343.33 g/mol (Anhydrous basis)
Synonyms	Fmoc-Ser-OH • H2O; Fmoc-L-Serine Hydrate; Fmoc-Serine Hydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine Hydrate; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-hydroxypropanoic acid hydrate; Fmoc-Ser hydrate; Nα-Fmoc-L-serine Hydrate; Fmoc-Ser-OH monohydrate
EINECS	Contact for details

Quality Control

Our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Hydroxypropanoic Acid Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (Anhydrous basis)
Optical Rotation	[α]D20: -15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	3.0% - 6.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.