Description

Trt-D-Hse(Me)-Oh Dea CAS NO 1272755-65-3 is a specialized, non-natural amino acid derivative featuring a trityl (Trt) protecting group on the side chain hydroxyl and a diethylamide (Dea) moiety. This compound is a critical building block in advanced pharmaceutical research, particularly for the synthesis of complex peptides and peptidomimetics with enhanced metabolic stability and receptor selectivity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for drug discovery programs targeting metabolic diseases, CNS disorders, and oncology.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the synthesis of novel therapeutic peptides and peptide-based drug candidates.
• Peptidomimetic Design: Used to incorporate modified amino acid residues that mimic natural peptide structures while improving pharmacokinetic properties like oral bioavailability.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected amino acid derivative in Fmoc/t-Bu or Boc/Bzl strategies for constructing complex peptide sequences.
• Chemical Biology Probes: Acts as a building block for creating labeled or tagged peptides used in mechanism-of-action studies and target identification.
• Process Chemistry & Scale-Up: Provides a defined, high-purity starting material for the development of robust and scalable synthetic routes to Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis, peptide chemistry, and medicinal chemistry.

Basic Information

Product Name	Trt-D-Hse(Me)-Oh Dea
CAS No.	1272755-65-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Diethyl-2-[(9H-fluoren-9-ylmethoxy)carbonyl]amino-4-(trityloxy)butanamide; Fmoc-D-Hse(Me)-OH Dea; Fmoc-D-O-methylhomoserine(triphenylmethyl)-OH diethylamide; D-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-4-(trityloxy)butanoic acid diethylamide; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(trityloxy)butanoic acid N,N-diethylamide; Fmoc-D-Hse(Trityl)-OH diethylamide; Fmoc-D-O-Me-Hser(Trt)-OH Dea
EINECS	Contact for details

Quality Control

Our Trt-D-Hse(Me)-Oh Dea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.