Description

(R)-1-Benzyl-5-Oxo-Pyrrolidin-2-Yl Acetonitrile CAS NO 1272755-31-3 is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its core value lies in its utility as a key building block for constructing complex, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and process engineers working in pharmaceutical manufacturing, agrochemical development, and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other enzyme-targeted therapeutics.
• Agrochemical Research: Serves as a precursor in the design and synthesis of novel, optically active pesticides and herbicides.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where specific chirality is required.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research within university and corporate laboratories.

Basic Information

Product Name	(R)-1-Benzyl-5-Oxo-Pyrrolidin-2-Yl Acetonitrile
CAS No.	1272755-31-3
Molecular Formula	C₁₄H₁₆N₂O
Molecular Weight	228.29 g/mol
Synonyms	(R)-1-Benzyl-5-oxopyrrolidine-2-acetonitrile; (2R)-1-Benzyl-5-oxo-2-pyrrolidineacetonitrile; (R)-1-Benzyl-2-(cyanomethyl)-5-pyrrolidinone; 2-Pyrrolidineacetonitrile, 1-benzyl-5-oxo-, (2R)-; (R)-α-((Benzylamino)methyl)-γ-butyrolactone cyanide derivative; (R)-1-Benzyl-5-oxopyrrolidine-2-acetonitrile; (R)-BNPA
EINECS	Contact for details

Quality Control

Our (R)-1-Benzyl-5-Oxo-Pyrrolidin-2-Yl Acetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.