Description

(R)-1-Benzyl-5-Chloromethyl-2-Pyrrolidinone CAS NO 1272755-28-8 is a high-value chiral intermediate featuring a pyrrolidinone core with a benzyl group and a reactive chloromethyl substituent. This compound is critical for the synthesis of complex, biologically active molecules where stereochemical purity is paramount. It is primarily sought by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Used as a precursor for chiral auxiliaries, ligands, or catalysts in stereoselective chemical transformations.
• API Development: Serves as a critical intermediate in the multi-step synthesis of complex target molecules during process development and scale-up.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring a defined (R)-configured pyrrolidinone scaffold.
• Academic & Contract Research: Utilized in research laboratories for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(R)-1-Benzyl-5-Chloromethyl-2-Pyrrolidinone
CAS No.	1272755-28-8
Molecular Formula	C12H14ClNO
Molecular Weight	223.70 g/mol
Synonyms	(R)-1-Benzyl-5-(chloromethyl)pyrrolidin-2-one; (R)-5-(Chloromethyl)-1-benzyl-2-pyrrolidinone; (R)-1-Benzyl-5-(chloromethyl)-2-pyrrolidinone; 1-Benzyl-5-chloromethyl-2-pyrrolidinone, (R)-; (R)-1-Bn-5-chloromethyl-2-pyrrolidinone; (R)-α-Benzyl-γ-chloromethyl-γ-butyrolactam
EINECS	Contact for details

Quality Control

Our (R)-1-Benzyl-5-Chloromethyl-2-Pyrrolidinone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chiral purity and chemical integrity, critical for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity (typically by HPLC), chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.