Description

(2S,3S)-N2-(9-Fluorenylmethyloxycarbonyl)-N3-Allyloxycarbonyl-2,3-Diaminobutyric Acid is a sophisticated, orthogonally protected diaminobutyric acid derivative designed for advanced peptide synthesis. This compound matters because it provides researchers with precise control over side-chain functionality, enabling the construction of complex peptides and peptidomimetics with specific stereochemistry. It is primarily needed by pharmaceutical R&D teams, biotech companies, and academic laboratories engaged in the development of novel therapeutic peptides, constrained analogs, and chemical biology probes. Its high-purity grade ensures reliable and reproducible results in critical synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of the 2,3-diaminobutyric acid (Dab) residue with specific (2S,3S) stereochemistry into peptide chains.
• Peptidomimetic Drug Discovery: Used to create conformationally constrained peptide analogs and macrocycles for enhancing metabolic stability and target binding affinity.
• Chemical Biology Probes: Enables the site-specific introduction of functional handles (via the Allyloxycarbonyl group) for bioconjugation, labeling, or further chemical modification.
• Antibiotic & Antimicrobial Peptide Research: Serves as a precursor for synthesizing analogs of natural and synthetic antimicrobial peptides that contain diaminobutyric acid motifs.
• GPCR Ligand Development: Facilitates the synthesis of peptide-based ligands where the Dab side chain is critical for receptor interaction and signaling modulation.
• Custom Peptide Service Providers: An essential raw material for CROs and manufacturers offering bespoke, high-complexity peptide synthesis services.

Basic Information

Product Name	(2S,3S)-N2-(9-Fluorenylmethyloxycarbonyl)-N3-Allyloxycarbonyl-2,3-Diaminobutyric Acid
CAS No.	1272754-91-2
Molecular Formula	C23H24N2O6
Molecular Weight	424.45 g/mol
Synonyms	Fmoc-Dab(Alloc)-OH; (2S,3S)-Fmoc-Dab(Alloc)-OH; Fmoc-L-Dab(Alloc)-OH; Nα-Fmoc-Nγ-Alloc-L-2,4-diaminobutyric acid; Nα-Fmoc-Nγ-Alloc-(2S,3S)-2,3-diaminobutyric acid; Fmoc-Dab(Alloc)-OH (2S,3S isomer); Alloc-Dab(Fmoc)-OH; 2,3-Diaminobutyric acid derivative, Fmoc/Alloc protected
EINECS	Contact for details

Quality Control

Our (2S,3S)-N2-(9-Fluorenylmethyloxycarbonyl)-N3-Allyloxycarbonyl-2,3-Diaminobutyric Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de (2S,3S)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.