Description

(S)-1-[(R)-2-[Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino]-Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in a range of transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer intermediates. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance ligands for complex synthetic transformations.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, critical for producing chiral pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to create stereogenic centers with high fidelity.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of enantiomerically pure active pharmaceutical ingredients (APIs) and key chiral intermediates.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and insecticides where biological activity is enantiomer-specific.
• Fine Chemical and Flavor/Fragrance Production: Enables the asymmetric synthesis of complex molecules for high-value specialty chemicals.
• Catalyst Screening and Development: A valuable tool in academic and industrial research for discovering and optimizing new catalytic systems.
• Process Chemistry and Scale-up: Provides robust performance for transitioning asymmetric reactions from laboratory to pilot and production scale.

Basic Information

Item	Details
Product Name	(S)-1-[(R)-2-[Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino]-Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine
CAS No.	1272317-38-0
Molecular Formula	C53H40F12FeP2
Molecular Weight	998.66 g/mol
Synonyms	(S,R)-TaniaPhos; TaniaPhos; (S)-1-[(R)-2-(Bis[3,5-bis(trifluoromethyl)phenyl]phosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; (S,R)-TaniaPhos ligand; TaniaPhos ferrocenyl ligand; (S,R)-TaniaPhos phosphine ligand; (S,R)-TaniaPhos (C53H40F12FeP2)
EINECS	Contact for details

Quality Control

Our (S)-1-[(R)-2-[Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino]-Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and should be handled in a controlled, moisture-free environment to maintain its catalytic efficacy.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.