Description

11-Deoxycortisol (21,21-D2, 96%) is a deuterium-labeled analog of the endogenous steroid hormone 11-deoxycortisol, a key intermediate in the biosynthesis of cortisol. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical workflows. It is primarily utilized by researchers and quality control laboratories in pharmaceutical development, clinical diagnostics, and endocrinology research.

Application

• Mass Spectrometry Internal Standard: Critical for the precise quantification of endogenous 11-deoxycortisol in LC-MS/MS and GC-MS methods.
• Clinical Diagnostics: Used in the development and validation of assays for diagnosing disorders of the hypothalamic-pituitary-adrenal (HPA) axis, such as congenital adrenal hyperplasia (CAH).
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetic (DMPK) studies to track the biotransformation of steroid-based pharmaceuticals.
• Endocrinology Research: Serves as a stable tracer in metabolic pathway studies to investigate cortisol synthesis and regulation.
• Reference Material: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring method compliance in regulated laboratories.

Basic Information

Product Name	11-Deoxycortisol (21,21-D2, 96%)
CAS No.	1271728-08-5
Molecular Formula	C21H28D2O4
Molecular Weight	348.48 g/mol
Synonyms	17α,21-Dihydroxypregn-4-ene-3,20-dione (21,21-D2); Cortexolone-d2; 17-Hydroxy-11-deoxycorticosterone-d2; Reichstein's Substance S-d2; 11-Deoxy-17-hydroxycorticosterone-d2; 21-Deoxycortisol-d2; (11β)-11-Deoxycortisol-d2
EINECS	Contact for details

Quality Control

Every batch of 11-Deoxycortisol (21,21-D2, 96%) is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing, including NMR and Mass Spectrometry for structural confirmation and isotopic enrichment verification, and HPLC for chemical and isotopic purity assessment. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with research and diagnostic application standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Isotopic Enrichment (MS)	≥ 96% D2
Chemical Purity (HPLC)	≥ 98.0%
Isotopic Purity (HPLC-MS)	≥ 96.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.